Enhanced Performance Solution for Tissue Grafts

Researchers at the University of Missouri have developed a novel solution to quickly conjugate nanoparticles to tissue grafts to improve graft performance. These grafts can be autografts (patient’s own tissue) or commercially available allografts, xenografts, or other natural materials such as collagen or 3D printed tissues. The nanoparticles can be any ceramic, metallic, polymeric, composite or degradable material. The procedure takes less than 15 minutes enabling it to be easily performed in surgical suite settings and making the enhanced graft readily available.

Background

Accurate and sensitive SNP detection is important in numerous fields within the life sciences. Standard methods rely on the cumulative electrostatic interactions between probe and target nucleic acids, resulting in a low power to discriminate between SNP and wild-type sequence at any single nucleotide position. MU’s technology uses modified oligonucleotide probes to create covalent bonds only at targeted SNPS to enable a novel and improved method to detect and/or capture SNP-specific nucleic acid sequences.

Applications

Detection of Single Nucleotide Polymorphism/Variation

Advantages

• Covalent crosslink enables greater detection sensitivity/specificity
• Compatible with any hybridization-based methods including nanopore and PCR

Additional Details