Preventing Herpes Simplex Virus Replication with a New Class of Drugs

Researchers at Saint Louis University have developed new derivatives of an N-hydroxypryidinone molecule that act as inhibitors of herpes simplex virus replication. Research is at the hit to lead optimization stage.

Herpes simplex viruses (HSV) are members of the human Herpesviridae family. HSV is categorized into two types, both of which are common and contagious. Worldwide an estimated 3.7 billion people under age 50 are infected with HSV-1 and about 417 million people ages 15-49 are infected with HSV-2. Currently available treatments do not cure HSV infections. Additionally, drug resistance is problematic with certain HSV patient populations.


The potential advantages of this technology over existing solutions include:

  • Minimizing the need for recurring treatment.
  • Increasing the effectiveness of treatments.
  • Minimizing drug resistance.
  • Minimizing toxicity of treatments.

Applications and Commercial Opportunities

Potential applications of this technology include treating and curing herpes simplex virus infections.

Additional Details

Owner: St. Louis University

IP Protection Status: Pending Patent